The science behind CXL and PACK-CXL
The article by Lu et al. reports an in vitro study, conducted to determine whether high-fluence PACK-CXL can be accelerated while still maintaining its antibacterial efficacy. The study found that high-fluence PACK-CXL did indeed decrease the bacterial concentration of several clinically significant bacterial strains, including S. aureus, P. aeruginosa, and S. epidermidis. These strains are commonly implicated in bacterial keratitis and contact lens-associated keratitis. Furthermore, the authors found that higher total fluence PACK-CXL protocols led to a corresponding increase in bacterial killing ratio (BKR).
The advantages of performing corneal cross-linking (CXL) at the slit lamp are well established. It brings CXL out of the operating theater, to anywhere where
It has been quite the debate. Should surgeons drop riboflavin onto the cornea during the UV irradiation part of a corneal cross-linking (CXL) procedure, or
Photoactivated chromophore for keratitis-corneal cross-linking (PACK-CXL) has progressed a great deal since it was first developed (1) as a treatment for infectious keratitis and corneal
Nikki Hafezi’s successful launch of slit lamp cross-linking technology.
It?s clear that there is a link between eye rubbing and keratoconus. Eye rubbing can alter the strength of the cornea, which can cause keratoconus to